The number of houses on the site will shrink by 128 to fit the new commercial development.
The application was prompted by the realignment of an access road, but comes as development work proceeds on an earlier 210,000 sq ft warehouse phase in six units.
A report to Trafford councillors said that there would be further commercial development. The entire Carrington site, which stretches to more than 1,600 acres, was once a Shell oil refinery and could see up to 4 million sq ft of warehousing and offices.
"It is anticipated that subsequent phases will seek to deliver further employment development on the brownfield land south and east of the application site (south of the A1 road), together with the potential for a new strategic road, providing significant improvement to the strategic highway network,” the report said.
Manchester-based HIMOR is behind construction of Carrington Gateway. Enabling works for future phase are being undertaken in 2018.